The prevalence is 0.4 per 100,000 people in Hong Kong and 0.65 per 100,000 in Japan. I saw a side of science that the public rarely, if ever, sees. Here is more information for caregivers and patients regarding family planning and relationships. The Scientific Approach to Evolution provides a rational new perspective on this debate. Though people with the HD allele will eventually show symptoms, there are many lifestyle choices that can make the disease easier to manage. 5. Moreover, results do not come cheaply. It is a collection of ideas and assumptions that are used to interpret reality. I was going from writing about science to actually doing science—a big leap. Multiple secondary antibodies bind to the primary, thereby amplifying the fluorescent signal. The pace of research can, however, be accelerated by adding more trained scientists, by building and using machines that can allow experiments or observations more quickly and without bias, and by increasing the rate of flow of accurate information about the research, both within the scientific community and from scientists to the public which, directly or indirectly, funds most of these efforts. Surya uses immunocytochemistry (IC), a method of staining cells with antibodies so that she can pinpoint the location of the huntingtin protein, for example, in the nuclei. One of the greatest rewards of scientific research is the “Eureka!” moment—that sudden gleeful breakthrough that can occur after much effort and many months of work. I am, however, familiar with the biology behind HD. Or researchers may try to use these new phenotypes to develop novel assays (chemical analyses) that can be used to discover drug compounds that may prevent the disease-associated phenotype. Because HD is inherited as a genetically dominant character, a person needs only one mutated copy of the gene, called the expanded HD CAG allele, to inherit the disease. It is the organized process of determining the accuracy of scientific theories through careful observation and experimentation. Welcome to the Research and HD section of the website! We emphasize that we are neither medical professionals, nor are we affiliated with the researchers and laboratories mentioned on our pages. My second experiment, therefore, was a repeat of the first. Here you will find reviews on published resources related to Huntington’s disease. He is positionned besides and slightly behind the leading aircraft. While science journalism is not, for the most part, intentionally fraudulent or misleading, it sometimes gives people the wrong impression about scientific findings by the way it interprets the data from recent articles in science journals like Cell and Human Molecular Genetics. While there is currently no cure for HD, there are drugs available to treat some of the symptoms, particularly chorea and depression. Here's how. Although the scientific community values collaboration, it does not necessarily frown upon competition. MIND, therefore, serves as a bridge between basic and clinical research. Our site is a “layperson’s guide” to the scientific intricacies of HD and HD-related research. For instance, Lakshmi Mysore, who has been working on HD for twenty years, specializes in genotyping, or determining the genetic makeup of an organism. Or do they require that you reject all your original hypotheses because you saw something new or unexpected? Working in a lab was a brand-new experience for me. The purpose of this section of our website is to approach all depictions of HD in the media with a critical lens media outlets often dramatize their depictions of medical conditions in an attempt to draw in viewers and readers. As of now, researchers only have a vague idea of the shape of the “building,” as specified by the genetic information on chromosome 4. There is no accurate data obtained from Thailand, Indonesia and Philippines. There is also a juvenile form of the disease whose symptoms commonly appear before the age of 20. Scientists do not leap from their lab benches crying, “Eureka!” every day, nor do they produce a continual stream of results. They found a CAG triplet repeat expansion in a region of human chromosome 4. She applies a primary antibody stain to mutant and wild-type cells on cover slips. Not only does it require patience from both the scientists and the public, but it also requires a great deal of intensive effort that includes collaboration between research teams in different parts of the country and around the world. Dr. MacDonald is one such researcher who works at the beginning of the disease pathway. In reality, the scientific method—that is, the process of empirical investigation into the validity or invalidity of a scientific claim or hypothesis—relies on replication and critical testing of each new finding, which takes a considerable amount of time. Although no cure exists, scientific research aimed at finding effective treatments for HD is underway.
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